' 
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7
USERS' SCORE
Good
Based on 14 Reviews
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
7
Folic acid shows limited protective effects
In vivo assay of the ethanol-induced embryonic hair cell loss and the protective role of the retinoic and folic acid in zebrafish larvae (Danio rerio).
Combined treatment yields positive results.
We explored the effects of folic acid on hair loss in zebrafish larvae after exposure to different concentrations of ethanol. This study revealed how gestational ethanol exposure can harm the development of sensory hair cells. We found that even small amounts of ethanol lead to a significant decrease in hair cell count.
When we co-treated the larvae with folic acid while still exposing them to ethanol, we noted a modest increase in the number of hair cells compared to those that only received ethanol. However, despite these benefits, the hair cell counts after folic acid treatment were still significantly lower than those of the control group that did not receive any ethanol or treatment.
Unfortunately, despite folic acid showing some protective effects, the results suggest it may not be enough on its own to fully prevent hair cell loss induced by ethanol. Thus, while folic acid can have a positive influence, its isolated impact on hair loss is not entirely clear due to concurrent ethanol exposure in this study. Therefore, we conclude that while folic acid does offer some benefit, more effective protection against hair cell loss may come from other treatments, such as retinoic acid.
When we co-treated the larvae with folic acid while still exposing them to ethanol, we noted a modest increase in the number of hair cells compared to those that only received ethanol. However, despite these benefits, the hair cell counts after folic acid treatment were still significantly lower than those of the control group that did not receive any ethanol or treatment.
Unfortunately, despite folic acid showing some protective effects, the results suggest it may not be enough on its own to fully prevent hair cell loss induced by ethanol. Thus, while folic acid can have a positive influence, its isolated impact on hair loss is not entirely clear due to concurrent ethanol exposure in this study. Therefore, we conclude that while folic acid does offer some benefit, more effective protection against hair cell loss may come from other treatments, such as retinoic acid.
Read More
7
Folate's role in hair growth unclear
L-Cystine-Containing Hair-Growth Formulation Supports Protection, Viability, and Proliferation of Keratinocytes.
Limited specific effect on hair loss
We investigated the effects of folate within a well-structured study that examined its role in hair loss treatments. Although part of a marketed oral combination for diffuse hair loss, folate's specific impact was challenging to isolate because it was evaluated alongside other compounds.
Our research utilized a minimal growth culture system to mimic the decreased activity of human hair follicular keratinocytes. We compared these cells cultured with and without four key compounds of the treatment, including folate. Our findings indicated that while the overall combination improved cell metabolism and proliferation, we couldn't clearly assess folate's individual contribution to preventing hair loss.
Ultimately, this approach revealed that L-cystine was more prominently linked to protective effects against oxidative stress, overshadowing any potential benefits from folate alone. As a result, we conclude that folate's direct effectiveness for hair growth remains ambiguous within this specific formulation and context.
Our research utilized a minimal growth culture system to mimic the decreased activity of human hair follicular keratinocytes. We compared these cells cultured with and without four key compounds of the treatment, including folate. Our findings indicated that while the overall combination improved cell metabolism and proliferation, we couldn't clearly assess folate's individual contribution to preventing hair loss.
Ultimately, this approach revealed that L-cystine was more prominently linked to protective effects against oxidative stress, overshadowing any potential benefits from folate alone. As a result, we conclude that folate's direct effectiveness for hair growth remains ambiguous within this specific formulation and context.
Read More
Most Useful Reviews
7.5
Reduced hair loss
I used it for a month and experienced lethargy, fatigue, and hair loss. Prior to using this, I suffered from spinning and dizziness, but that has now disappeared. Additionally, I have noticed less hair loss. If my comment helps you, please give me a like 🤩.
Read More
9.5
Stopped hair loss
This has been a great addition and solution. I struggled with hair loss for a long time without success. Following my doctor's advice, I was tested for anemia, revealing low ferritin and deficiencies in B12 and B9. After taking this complex with Sorbifer, my hair loss ceased and I even experienced a newfound cheerfulness. I also supplement with VitD3 and magnesium, and I will continue using this.
Read More
9.5
Enhanced energy levels
When taking B vitamins, I always seek methylated forms as many people have the MTHFR gene and struggle to absorb certain B vitamins, especially B12 and folate. Since starting these, I feel more energetic, less pale, and my hair is not falling out. B vitamins are crucial for a healthy nervous system and overall wellbeing.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7
- All Researches
7
Folate's role in hair growth unclear
L-Cystine-Containing Hair-Growth Formulation Supports Protection, Viability, and Proliferation of Keratinocytes.
Limited specific effect on hair loss
We investigated the effects of folate within a well-structured study that examined its role in hair loss treatments. Although part of a marketed oral combination for diffuse hair loss, folate's specific impact was challenging to isolate because it was evaluated alongside other compounds.
Our research utilized a minimal growth culture system to mimic the decreased activity of human hair follicular keratinocytes. We compared these cells cultured with and without four key compounds of the treatment, including folate. Our findings indicated that while the overall combination improved cell metabolism and proliferation, we couldn't clearly assess folate's individual contribution to preventing hair loss.
Ultimately, this approach revealed that L-cystine was more prominently linked to protective effects against oxidative stress, overshadowing any potential benefits from folate alone. As a result, we conclude that folate's direct effectiveness for hair growth remains ambiguous within this specific formulation and context.
Our research utilized a minimal growth culture system to mimic the decreased activity of human hair follicular keratinocytes. We compared these cells cultured with and without four key compounds of the treatment, including folate. Our findings indicated that while the overall combination improved cell metabolism and proliferation, we couldn't clearly assess folate's individual contribution to preventing hair loss.
Ultimately, this approach revealed that L-cystine was more prominently linked to protective effects against oxidative stress, overshadowing any potential benefits from folate alone. As a result, we conclude that folate's direct effectiveness for hair growth remains ambiguous within this specific formulation and context.
Read More
7
Folic acid shows limited protective effects
In vivo assay of the ethanol-induced embryonic hair cell loss and the protective role of the retinoic and folic acid in zebrafish larvae (Danio rerio).
Combined treatment yields positive results.
We explored the effects of folic acid on hair loss in zebrafish larvae after exposure to different concentrations of ethanol. This study revealed how gestational ethanol exposure can harm the development of sensory hair cells. We found that even small amounts of ethanol lead to a significant decrease in hair cell count.
When we co-treated the larvae with folic acid while still exposing them to ethanol, we noted a modest increase in the number of hair cells compared to those that only received ethanol. However, despite these benefits, the hair cell counts after folic acid treatment were still significantly lower than those of the control group that did not receive any ethanol or treatment.
Unfortunately, despite folic acid showing some protective effects, the results suggest it may not be enough on its own to fully prevent hair cell loss induced by ethanol. Thus, while folic acid can have a positive influence, its isolated impact on hair loss is not entirely clear due to concurrent ethanol exposure in this study. Therefore, we conclude that while folic acid does offer some benefit, more effective protection against hair cell loss may come from other treatments, such as retinoic acid.
When we co-treated the larvae with folic acid while still exposing them to ethanol, we noted a modest increase in the number of hair cells compared to those that only received ethanol. However, despite these benefits, the hair cell counts after folic acid treatment were still significantly lower than those of the control group that did not receive any ethanol or treatment.
Unfortunately, despite folic acid showing some protective effects, the results suggest it may not be enough on its own to fully prevent hair cell loss induced by ethanol. Thus, while folic acid can have a positive influence, its isolated impact on hair loss is not entirely clear due to concurrent ethanol exposure in this study. Therefore, we conclude that while folic acid does offer some benefit, more effective protection against hair cell loss may come from other treatments, such as retinoic acid.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduced hair loss
I used it for a month and experienced lethargy, fatigue, and hair loss. Prior to using this, I suffered from spinning and dizziness, but that has now disappeared. Additionally, I have noticed less hair loss. If my comment helps you, please give me a like 🤩.
9.5
Stopped hair loss
This has been a great addition and solution. I struggled with hair loss for a long time without success. Following my doctor's advice, I was tested for anemia, revealing low ferritin and deficiencies in B12 and B9. After taking this complex with Sorbifer, my hair loss ceased and I even experienced a newfound cheerfulness. I also supplement with VitD3 and magnesium, and I will continue using this.
Read More
9.5
Enhanced energy levels
When taking B vitamins, I always seek methylated forms as many people have the MTHFR gene and struggle to absorb certain B vitamins, especially B12 and folate. Since starting these, I feel more energetic, less pale, and my hair is not falling out. B vitamins are crucial for a healthy nervous system and overall wellbeing.
Read More
9.5
Coping with hair loss
This medication helped me manage hair loss. My tests indicated a low B12 level, and since using this, I have seen improvements.
9.5
Significant improvement
Good quality. I took it for hair loss on my doctor's advice, as I dislike meat and had low hemoglobin. Vitamin B12 is vital for the nervous system and red blood cell formation and is effective for anemia treatment. After the complex treatment, my well-being improved significantly, and the hair loss stopped. I didn't particularly enjoy the taste, so I swallowed it whole.
Read More
