Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.4
USERS' SCORE
Good
Based on 14 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
8
We examined a new strain derived from the human microbiome, Cicaria, to see how it helps with hair loss. Through testing on individuals with hair loss and comparing them to a control group with normal scalps, we found that Cicaria produced key compounds like adenosine and biotin. Notably, hair follicles treated with these elements displayed longer lengths and maintained healthier root diameters. Furthermore, these treatments appeared to support the phases of hair growth, slowing the transition to hair loss. Thus, Cicaria shows potential as a treatment for hair loss.
Read More
8
We explored the effects of Dexpanthenol, a vitamin B5 precursor, on hair follicle cells. Our findings showed that Dexpanthenol boosted cell viability and proliferation in human dermal papilla and outer root sheath cells. It reduced markers of cell aging and death while promoting factors that extend the hair growth phase.
However, our results indicate that while Dexpanthenol may have potential for stimulating hair growth through these mechanisms, further studies are necessary to establish its effectiveness in combating hair loss more broadly.
However, our results indicate that while Dexpanthenol may have potential for stimulating hair growth through these mechanisms, further studies are necessary to establish its effectiveness in combating hair loss more broadly.
Read More
8
Valproic acid treatment and hair loss
We explored the relationship between antiepileptic medications, specifically valproic acid and carbamazepine, and various serum levels in children.
Our findings indicated no significant changes in biotin or biotinidase enzyme levels between the medication groups and healthy controls. However, we noted lower zinc levels in both treatment groups, though still within normal limits.
Interestingly, three participants on valproic acid experienced hair loss. Remarkably, this issue resolved after a three-month regimen of biotin supplementation, suggesting a potential benefit of biotin for hair health.
Our findings indicated no significant changes in biotin or biotinidase enzyme levels between the medication groups and healthy controls. However, we noted lower zinc levels in both treatment groups, though still within normal limits.
Interestingly, three participants on valproic acid experienced hair loss. Remarkably, this issue resolved after a three-month regimen of biotin supplementation, suggesting a potential benefit of biotin for hair health.
Read More
Most Useful Reviews
7.5
Reduced hair loss
10 people found this helpful
I used it for a month and experienced lethargy, fatigue, and hair loss. Prior to using this, I suffered from spinning and dizziness, but that has now disappeared. Additionally, I have noticed less hair loss. If my comment helps you, please give me a like 🤩.
Read More
9
Stopped hair loss
3 people found this helpful
This has been a great addition and solution. I struggled with hair loss for a long time without success. Following my doctor's advice, I was tested for anemia, revealing low ferritin and deficiencies in B12 and B9. After taking this complex with Sorbifer, my hair loss ceased and I even experienced a newfound cheerfulness. I also supplement with VitD3 and magnesium, and I will continue using this.
Read More
9
Enhanced energy levels
1 people found this helpful
When taking B vitamins, I always seek methylated forms as many people have the MTHFR gene and struggle to absorb certain B vitamins, especially B12 and folate. Since starting these, I feel more energetic, less pale, and my hair is not falling out. B vitamins are crucial for a healthy nervous system and overall wellbeing.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.4
- All Researches
8
We examined a new strain derived from the human microbiome, Cicaria, to see how it helps with hair loss. Through testing on individuals with hair loss and comparing them to a control group with normal scalps, we found that Cicaria produced key compounds like adenosine and biotin. Notably, hair follicles treated with these elements displayed longer lengths and maintained healthier root diameters. Furthermore, these treatments appeared to support the phases of hair growth, slowing the transition to hair loss. Thus, Cicaria shows potential as a treatment for hair loss.
Read More
8
We explored the effects of Dexpanthenol, a vitamin B5 precursor, on hair follicle cells. Our findings showed that Dexpanthenol boosted cell viability and proliferation in human dermal papilla and outer root sheath cells. It reduced markers of cell aging and death while promoting factors that extend the hair growth phase.
However, our results indicate that while Dexpanthenol may have potential for stimulating hair growth through these mechanisms, further studies are necessary to establish its effectiveness in combating hair loss more broadly.
However, our results indicate that while Dexpanthenol may have potential for stimulating hair growth through these mechanisms, further studies are necessary to establish its effectiveness in combating hair loss more broadly.
Read More
8
Valproic acid treatment and hair loss
We explored the relationship between antiepileptic medications, specifically valproic acid and carbamazepine, and various serum levels in children.
Our findings indicated no significant changes in biotin or biotinidase enzyme levels between the medication groups and healthy controls. However, we noted lower zinc levels in both treatment groups, though still within normal limits.
Interestingly, three participants on valproic acid experienced hair loss. Remarkably, this issue resolved after a three-month regimen of biotin supplementation, suggesting a potential benefit of biotin for hair health.
Our findings indicated no significant changes in biotin or biotinidase enzyme levels between the medication groups and healthy controls. However, we noted lower zinc levels in both treatment groups, though still within normal limits.
Interestingly, three participants on valproic acid experienced hair loss. Remarkably, this issue resolved after a three-month regimen of biotin supplementation, suggesting a potential benefit of biotin for hair health.
Read More
7
Topical solution shows promise in hair loss
We explored the effectiveness of a new topical formulation combining minoxidil, finasteride, biotin, and caffeine on male androgenetic alopecia, which is a common hair loss condition. Over six months, five participants applied the solution daily and attended regular evaluations.
By the end of the study, all patients showed noticeable improvements in hair thickness and overall appearance. While satisfaction levels varied, with some reporting neutral reactions at the three-month mark, most recognized benefits after six months. This suggests that the formulation could be a promising option for treating hair loss in men.
By the end of the study, all patients showed noticeable improvements in hair thickness and overall appearance. While satisfaction levels varied, with some reporting neutral reactions at the three-month mark, most recognized benefits after six months. This suggests that the formulation could be a promising option for treating hair loss in men.
Read More
7
We evaluated the effects of vitamin B6 and calcium pantothenate on hair loss in 46 women with diffuse alopecia. Over 4-5 months, participants received calcium pantothenate, while vitamin B6 was injected daily for 20-30 days, then again after six months.
Our findings highlighted that vitamin B6 significantly improved hair condition and reduced hair loss, especially in cases related to telogenic alopecia. However, calcium pantothenate did not demonstrate a notable positive effect in treating female hair loss.
Our findings highlighted that vitamin B6 significantly improved hair condition and reduced hair loss, especially in cases related to telogenic alopecia. However, calcium pantothenate did not demonstrate a notable positive effect in treating female hair loss.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduced hair loss
10 people found this helpful
I used it for a month and experienced lethargy, fatigue, and hair loss. Prior to using this, I suffered from spinning and dizziness, but that has now disappeared. Additionally, I have noticed less hair loss. If my comment helps you, please give me a like 🤩.
Read More
9
Stopped hair loss
3 people found this helpful
This has been a great addition and solution. I struggled with hair loss for a long time without success. Following my doctor's advice, I was tested for anemia, revealing low ferritin and deficiencies in B12 and B9. After taking this complex with Sorbifer, my hair loss ceased and I even experienced a newfound cheerfulness. I also supplement with VitD3 and magnesium, and I will continue using this.
Read More
9
Enhanced energy levels
1 people found this helpful
When taking B vitamins, I always seek methylated forms as many people have the MTHFR gene and struggle to absorb certain B vitamins, especially B12 and folate. Since starting these, I feel more energetic, less pale, and my hair is not falling out. B vitamins are crucial for a healthy nervous system and overall wellbeing.
Read More
9
Coping with hair loss
This medication helped me manage hair loss. My tests indicated a low B12 level, and since using this, I have seen improvements.
Read More
9
Significant improvement
Good quality. I took it for hair loss on my doctor's advice, as I dislike meat and had low hemoglobin. Vitamin B12 is vital for the nervous system and red blood cell formation and is effective for anemia treatment. After the complex treatment, my well-being improved significantly, and the hair loss stopped. I didn't particularly enjoy the taste, so I swallowed it whole.
Read More
Frequently Asked Questions
7.5
Noticeable reduction
Quality brand. I love the taste, and I've noticed the effects after a week—much less hair loss.
7.5
Less hair loss
B vitamins are essential for the circulatory and cardiovascular systems. A lack of B vitamins leads to increased hair loss and brittle nails. My doctor prescribed this vitamin, and after two months, my homocysteine levels decreased and hair loss diminished. It tastes good; I took 2 tablets in the morning after breakfast.
9
Coping with hair loss
This medication helped me manage hair loss. My tests indicated a low B12 level, and since using this, I have seen improvements.
9
Stopped hair loss
3 people found this helpful
This has been a great addition and solution. I struggled with hair loss for a long time without success. Following my doctor's advice, I was tested for anemia, revealing low ferritin and deficiencies in B12 and B9. After taking this complex with Sorbifer, my hair loss ceased and I even experienced a newfound cheerfulness. I also supplement with VitD3 and magnesium, and I will continue using this.
9
Enhanced energy levels
1 people found this helpful
When taking B vitamins, I always seek methylated forms as many people have the MTHFR gene and struggle to absorb certain B vitamins, especially B12 and folate. Since starting these, I feel more energetic, less pale, and my hair is not falling out. B vitamins are crucial for a healthy nervous system and overall wellbeing.
7.5
Stronger hair
7 people found this helpful
I find this form of vitamin B12 convenient and it is well absorbed by my body. I’ve noticed visible changes, including less hair loss and improved nail strength. This is my second bottle, and I recommend it to anyone with low hemoglobin due to B12 deficiency.
9
Significant improvement
Good quality. I took it for hair loss on my doctor's advice, as I dislike meat and had low hemoglobin. Vitamin B12 is vital for the nervous system and red blood cell formation and is effective for anemia treatment. After the complex treatment, my well-being improved significantly, and the hair loss stopped. I didn't particularly enjoy the taste, so I swallowed it whole.
8
We examined a new strain derived from the human microbiome, Cicaria, to see how it helps with hair loss. Through testing on individuals with hair loss and comparing them to a control group with normal scalps, we found that Cicaria produced key compounds like adenosine and biotin. Notably, hair follicles treated with these elements displayed longer lengths and maintained healthier root diameters. Furthermore, these treatments appeared to support the phases of hair growth, slowing the transition to hair loss. Thus, Cicaria shows potential as a treatment for hair loss.
8
We explored the effects of Dexpanthenol, a vitamin B5 precursor, on hair follicle cells. Our findings showed that Dexpanthenol boosted cell viability and proliferation in human dermal papilla and outer root sheath cells. It reduced markers of cell aging and death while promoting factors that extend the hair growth phase.
However, our results indicate that while Dexpanthenol may have potential for stimulating hair growth through these mechanisms, further studies are necessary to establish its effectiveness in combating hair loss more broadly.
However, our results indicate that while Dexpanthenol may have potential for stimulating hair growth through these mechanisms, further studies are necessary to establish its effectiveness in combating hair loss more broadly.
8
Valproic acid treatment and hair loss
We explored the relationship between antiepileptic medications, specifically valproic acid and carbamazepine, and various serum levels in children.
Our findings indicated no significant changes in biotin or biotinidase enzyme levels between the medication groups and healthy controls. However, we noted lower zinc levels in both treatment groups, though still within normal limits.
Interestingly, three participants on valproic acid experienced hair loss. Remarkably, this issue resolved after a three-month regimen of biotin supplementation, suggesting a potential benefit of biotin for hair health.
Our findings indicated no significant changes in biotin or biotinidase enzyme levels between the medication groups and healthy controls. However, we noted lower zinc levels in both treatment groups, though still within normal limits.
Interestingly, three participants on valproic acid experienced hair loss. Remarkably, this issue resolved after a three-month regimen of biotin supplementation, suggesting a potential benefit of biotin for hair health.
7
We investigated the effects of folate within a well-structured study that examined its role in hair loss treatments. Although part of a marketed oral combination for diffuse hair loss, folate's specific impact was challenging to isolate because it was evaluated alongside other compounds.
Our research utilized a minimal growth culture system to mimic the decreased activity of human hair follicular keratinocytes. We compared these cells cultured with and without four key compounds of the treatment, including folate. Our findings indicated that while the overall combination improved cell metabolism and proliferation, we couldn't clearly assess folate's individual contribution to preventing hair loss.
Ultimately, this approach revealed that L-cystine was more prominently linked to protective effects against oxidative stress, overshadowing any potential benefits from folate alone. As a result, we conclude that folate's direct effectiveness for hair growth remains ambiguous within this specific formulation and context.
Our research utilized a minimal growth culture system to mimic the decreased activity of human hair follicular keratinocytes. We compared these cells cultured with and without four key compounds of the treatment, including folate. Our findings indicated that while the overall combination improved cell metabolism and proliferation, we couldn't clearly assess folate's individual contribution to preventing hair loss.
Ultimately, this approach revealed that L-cystine was more prominently linked to protective effects against oxidative stress, overshadowing any potential benefits from folate alone. As a result, we conclude that folate's direct effectiveness for hair growth remains ambiguous within this specific formulation and context.
References
- Jo H, Kim SY, Kang BH, Baek C, Kwon JE, et al. Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss. Molecules. 2022;27. 10.3390/molecules27165136
- Shin JY, Kim J, Choi YH, Kang NG, Lee S. Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells. Curr Issues Mol Biol. 2021;43:1361. 10.3390/cimb43030097
- Marotta JC, Patel G, Carvalho M, Blakeney S. Clinical Efficacy of a Topical Compounded Formulation in Male Androgenetic Alopecia: Minoxidil 10%, Finasteride 0.1%, Biotin 0.2%, and Caffeine Citrate 0.05% Hydroalcoholic Solution. Int J Pharm Compd. 2020;24:69.
- Castro-Gago M, PĂ©rez-Gay L, GĂłmez-Lado C, Castiñeiras-Ramos DE, Otero-MartĂnez S, et al. The influence of valproic acid and carbamazepine treatment on serum biotin and zinc levels and on biotinidase activity. J Child Neurol. 2011;26:1522. 10.1177/0883073811409227
- Brzezińska-Wcisło L. [Evaluation of vitamin B6 and calcium pantothenate effectiveness on hair growth from clinical and trichographic aspects for treatment of diffuse alopecia in women]. Wiad Lek. 2001;54:11.
- Riegel K, Hengl T, Krischok S, Schlinzig K, Abts HF. L-Cystine-Containing Hair-Growth Formulation Supports Protection, Viability, and Proliferation of Keratinocytes. Clin Cosmet Investig Dermatol. 2020;13:499. 10.2147/CCID.S254720
- Rah YC, Park S, Koun S, Park HC, Choi J. In vivo assay of the ethanol-induced embryonic hair cell loss and the protective role of the retinoic and folic acid in zebrafish larvae (Danio rerio). Alcohol. 2019;75:113. 10.1016/j.alcohol.2018.07.008
